Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873493 | 0.94 | MCHR1 (0.46) | MCHR1HRH3KDM4EMAPTALDH1A1 | |
| SCHEMBL6558013 | 0.80 | ALDH1A1 (0.49) | MCHR1MAPTALDH1A1LMNAPOLB | |
| SCHEMBL4847239 | 0.74 | CHRNA7 (0.46) | KDM4ELMNAPOLBCASP6 | |
| SCHEMBL5873479 | 0.72 | ALDH1A1 (0.54) | MCHR1ALDH1A1LMNA | |
| SCHEMBL5873568 | 0.69 | MAP4K4 (0.51) | HRH3KDM4EALDH1A1PLAULMNA | |
| SCHEMBL6559810 | 0.69 | MCHR1 (0.42) | MCHR1HRH3PLAU | |
| SCHEMBL5873732 | 0.68 | MCHR1 (0.43) | MCHR1HRH3 | |
| SCHEMBL6557970 | 0.66 | MCHR1 (0.59) | MCHR1HRH3 | |
| SCHEMBL29209061 | 0.65 | KDM4E (0.50) | HRH3KDM4EALDH1A1TDP1PLAU | |
| SCHEMBL5873634 | 0.65 | MCHR1 (0.75) | MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450801-A2 | 2-AMINOQUINOLINE COMPOUNDS | Merck & Co., Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045313-A2 | 2-AMINOQUINOLINE COMPOUNDS | MERCK & CO. INC. (US) | 2003-06-05 | — | — | WO | disclosed |