Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.71 |
| ▸ | GLA | P06280 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.71 |
| ▸ | ERAP1 | Q9NZ08 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560136 | 0.94 | KDM4E (0.64) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL14756049 | 0.93 | GAA (0.70) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL15211319 | 0.90 | MCL1 (0.66) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL6561714 | 0.88 | KDM4E (0.58) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL15295521 | 0.87 | MCL1 (0.70) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL15984890 | 0.85 | KDM4E (0.64) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL11079352 | 0.85 | GAA (0.63) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL15082524 | 0.84 | GAA (0.62) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL31454860 | 0.83 | ALDH1A1 (0.58) | GAAKDM4EGLAALDH1A1HPGD | |
| SCHEMBL17615425 | 0.82 | ERN1 (0.66) | GAAKDM4EGLAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |