Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | GLA | P06280 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 2/20 | 0.57 |
| ▸ | CASP7 | P55210 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ERAP1 | Q9NZ08 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560136 | 0.88 | KDM4E (0.64) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL6559997 | 0.88 | GAA (0.71) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL15211319 | 0.84 | MCL1 (0.66) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL6561597 | 0.82 | ALDH1A1 (0.51) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL14756049 | 0.81 | GAA (0.70) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL11079352 | 0.80 | GAA (0.63) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL5205948 | 0.79 | KDM4E (0.37) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL1594333 | 0.78 | CSNK2A2 (0.61) | KDM4EGAAALDH1A1GLAHPGD | |
| SCHEMBL6559981 | 0.76 | PDE5A (0.48) | KDM4EALDH1A1HPGDKMT2APOLB | |
| SCHEMBL15295521 | 0.75 | MCL1 (0.70) | KDM4EGAAALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |