Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861296 | 1.00 | DRD3 (0.64) | DRD3FYNCYP2D6ALDH1A1CYP2C9 | |
| SCHEMBL6250921 | 0.89 | DRD3 (0.50) | DRD3FYNCYP2D6ALDH1A1CYP2C9 | |
| SCHEMBL6561256 | 0.88 | DRD2 (0.67) | DRD3FYNCYP2D6DRD2DRD4 | |
| SCHEMBL30612408 | 0.88 | DRD2 (0.67) | DRD3FYNCYP2D6DRD2DRD4 | |
| SCHEMBL7449296 | 0.88 | DRD2 (0.70) | DRD3FYNCYP2D6DRD2DRD4 | |
| SCHEMBL6558764 | 0.88 | DRD2 (0.70) | DRD3FYNCYP2D6DRD2DRD4 | |
| SCHEMBL7451185 | 0.86 | DRD3 (0.55) | DRD3FYNDRD2DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL7448937 | 0.85 | DRD3 (0.54) | DRD3DRD2DRD4HTR1A | |
| SCHEMBL8689191 | 0.81 | DRD3 (0.66) | DRD3FYNCYP2D6ALDH1A1CYP2C9 | |
| SCHEMBL7862705 | 0.81 | DRD3 (0.60) | DRD3FYNCYP2D6ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |