Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.67 |
| ▸ | DRD3 | P35462 | 14/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | DRD4 | P21917 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30612408 | 1.00 | DRD2 (0.67) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL7449296 | 0.94 | DRD2 (0.70) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL6558764 | 0.94 | DRD2 (0.70) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL24740688 | 0.88 | DRD2 (0.51) | DRD2DRD3HTR1ADRD4MEN1 | |
| SCHEMBL7861296 | 0.88 | DRD3 (0.64) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL6560127 | 0.88 | DRD3 (0.64) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL9776894 | 0.86 | DRD2 (0.59) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL6931453 | 0.82 | DRD2 (0.67) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL7499793 | 0.82 | DRD2 (0.89) | DRD2DRD3HTR1AFYNDRD4 | |
| SCHEMBL9776853 | 0.82 | DRD2 (0.54) | DRD2DRD3HTR1ADRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810111-B | Pyrazolopyrimidine compound, and preparation method and application thereof | 上海医药集团股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |
| EP-0055043-B1 | 6,7,8,9-TETRAHYDRO-3H-BENZ(E)INDOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND INTERMEDIATES USED THEREIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE INDOLAMINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-01-23 | — | — | EP | disclosed |
| EP-0055043-A2 | 6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-06-30 | — | — | EP | disclosed |