Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.70 |
| ▸ | DRD3 | P35462 | 11/20 | 0.70 |
| ▸ | DRD4 | P21917 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.70 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CASP1 | P29466 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558764 | 1.00 | DRD2 (0.70) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6561256 | 0.94 | DRD2 (0.67) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL30612408 | 0.94 | DRD2 (0.67) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL9776894 | 0.92 | DRD2 (0.59) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL9776853 | 0.88 | DRD2 (0.54) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL7861296 | 0.88 | DRD3 (0.64) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6560127 | 0.88 | DRD3 (0.64) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL10447131 | 0.87 | DRD2 (0.66) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL17446285 | 0.84 | DRD2 (0.72) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL7400728 | 0.83 | DRD3 (0.67) | DRD2DRD3DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |