SCHEMBL6560165

SCHEMBL6560165

C=C(C)C(=O)NC12CC3CC(NC(=O)C(=C)C)(C1)CC(NC(=O)C(=C)C)(C3)C2

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 10/20 0.39
EPHX1 P07099 2/20 0.38
HDAC1 Q13547 4/20 0.36
HDAC8 Q9BY41 4/20 0.36
HDAC6 Q9UBN7 4/20 0.36
HDAC3 O15379 3/20 0.36
GAA P10253 1/20 0.36
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6560547 0.89 TSHR (0.47) EPHX2EPHX1GAATSHR
SCHEMBL12783371 0.88 EPHX1 (0.37) EPHX2EPHX1HDAC1HDAC8HDAC6
SCHEMBL6559951 0.85 ALDH1A1 (0.35)
SCHEMBL584409 0.84 EPHX2 (0.57) EPHX2EPHX1GAA
SCHEMBL4086300 0.81 EPHX1 (0.36) EPHX2EPHX1GAA
SCHEMBL12783362 0.79 TSHR (0.43) EPHX2EPHX1GAATSHR
SCHEMBL17829503 0.76 TSHR (0.40) EPHX2EPHX1GAATSHR
SCHEMBL21427871 0.74 EPHX2 (0.48) EPHX2EPHX1GAA
SCHEMBL1733449 0.73 ALDH1A1 (0.30)
SCHEMBL7636763 0.71 EPHX1 (0.44) EPHX2EPHX1HDAC1HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0915077-B1 POLYMERIZABLE ADAMANTANE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME DAICEL CHEM (JP) 2004-11-17 EP disclosed
US-6235851-B1 ESTERIFICATION OR AMIDATION REACTION OF AN ADAMANTANE DERIVATIVE; GROUP 3A METAL CATALYST DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0915077-A1 POLYMERIZABLE ADAMANTANE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME Daicel Chemical Industries, Ltd. (JP) 1999-05-12 EP disclosed