Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.61 |
| ▸ | CASP6 | P55212 | 1/20 | 0.61 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070016 | 0.96 | CYP1A2 (0.63) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL2151177 | 0.80 | GRK2 (0.68) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL7722861 | 0.79 | CYP1A2 (0.63) | TDP1CYP1A2RECQLGAAALDH1A1 | |
| SCHEMBL29140365 | 0.78 | CYP1A2 (0.61) | CASP6CYP1A2RECQLALDH1A1KMT2A | |
| SCHEMBL3926664 | 0.77 | GRK2 (0.64) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL10742560 | 0.77 | CYP1A2 (0.68) | TDP1L3MBTL1CYP1A2RECQLGAA | |
| SCHEMBL7726536 | 0.76 | CYP1A2 (0.62) | CYP1A2RECQLALDH1A1MAPTKMT2A | |
| SCHEMBL28153265 | 0.75 | EPHX1 (0.52) | CYP1A2RECQLALDH1A1KMT2AMCL1 | |
| SCHEMBL6560372 | 0.75 | GRK2 (0.48) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL28431130 | 0.72 | GRK2 (0.58) | GRK2CASP6CASP8CTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598396-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-21 | — | — | US | disclosed |
| US-9598396-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-21 | — | — | US | disclosed |
| US-20150353526-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-10 | — | — | US | disclosed |
| US-20150353526-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-10 | — | — | US | disclosed |
| US-9150540-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-06 | — | — | US | disclosed |
| US-9150540-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-06 | — | — | US | disclosed |
| US-20150038521-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-05 | — | — | US | disclosed |
| US-20150038521-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-05 | — | — | US | disclosed |
| EP-2271626-B1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-11-26 | — | — | EP | disclosed |
| US-8889866-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-18 | — | — | US | disclosed |
| US-8889866-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-18 | — | — | US | disclosed |
| US-20110263622-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN-CILAG (BE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263622-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN-CILAG (BE) | 2011-10-27 | — | — | US | disclosed |
| WO-2009118382-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263622-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | PARP1, PARP15, PARP11 | GRK2 1231/4885CASP6 1250/4885CASP8 2151/4885 |
| US-20150353526-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | PARP1, PARP15, PARP11 | GRK2 1231/4885CASP6 1250/4885CASP8 2151/4885 |
| US-20150038521-A1 | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS | PARP1, PARP15, PARP11 | GRK2 1231/4885CASP6 1250/4885CASP8 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.