Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561877 | 1.00 | NPC1 (0.51) | NPC1RAB9ALMNAKMT2APLK1 | |
| SCHEMBL6560669 | 0.83 | NPC1 (0.51) | NPC1RAB9ALMNAKMT2APLK1 | |
| SCHEMBL6561900 | 0.83 | NPC1 (0.51) | NPC1RAB9ALMNAKMT2APLK1 | |
| SCHEMBL6562118 | 0.82 | KMT2A (0.50) | NPC1RAB9ALMNAKMT2APLK1 | |
| SCHEMBL6561831 | 0.79 | NPC1 (0.43) | NPC1RAB9ALMNAKMT2APLK1 | |
| SCHEMBL6561769 | 0.79 | NPC1 (0.43) | NPC1RAB9ALMNAKMT2APLK1 | |
| SCHEMBL6560700 | 0.78 | NPC1 (0.51) | NPC1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL6357074 | 0.78 | KMT2A (0.68) | NPC1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL6563253 | 0.75 | TSHR (0.45) | NPC1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL6563249 | 0.75 | TSHR (0.45) | NPC1RAB9ALMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944581-A4 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | LILLY CO ELI (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-0944581-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998022429-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1998-05-28 | — | — | WO | disclosed |