Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560672 | 0.84 | CACNA1B (0.52) | NPC1RAB9ATDP1L3MBTL1USP2 | |
| SCHEMBL6561877 | 0.78 | NPC1 (0.51) | NPC1RAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL6560697 | 0.78 | NPC1 (0.51) | NPC1RAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL6561872 | 0.75 | ALDH1A1 (0.52) | NPC1RAB9ATDP1LMNATP53 | |
| SCHEMBL4569297 | 0.70 | HPGD (0.69) | NPC1RAB9ALMNATP53ALDH1A1 | |
| SCHEMBL580634 | 0.70 | USP2 (0.71) | NPC1RAB9ATDP1ATMUSP2 | |
| SCHEMBL6357074 | 0.69 | KMT2A (0.68) | NPC1RAB9ALMNATP53ALDH1A1 | |
| SCHEMBL3369060 | 0.68 | HTT (0.76) | NPC1RAB9ATDP1LMNAALDH1A1 | |
| SCHEMBL10062017 | 0.68 | NPC1 (1.00) | NPC1RAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7805240 | 0.67 | HTT (0.48) | NPC1RAB9ATDP1L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944581-A4 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | LILLY CO ELI (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-0944581-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998022429-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1998-05-28 | — | — | WO | disclosed |