Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560708 | 0.88 | MAPT (0.56) | CHEK2TDP1L3MBTL1KMT2AMAPT | |
| SCHEMBL8902416 | 0.84 | MAPT (0.57) | CHEK2TDP1L3MBTL1KMT2AMAPT | |
| SCHEMBL3866051 | 0.84 | CHEK2 (0.56) | CHEK2KMT2AHRH2HRH1 | |
| SCHEMBL5706378 | 0.83 | CHEK2 (0.55) | CHEK2HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL6561583 | 0.83 | CHEK2 (0.55) | CHEK2KMT2AHRH2HRH1 | |
| Hydrochloric Acid SCHEMBL6560096 | 0.81 | CHEK2 (0.54) | CHEK2HRH2HRH1 | |
| SCHEMBL6004777 | 0.81 | CHEK2 (0.54) | CHEK2HRH2HRH1 | |
| SCHEMBL7317389 | 0.81 | KCNH2 (0.56) | HRH3KCNH2TDP1L3MBTL1MAPT | |
| SCHEMBL6704387 | 0.81 | HSP90AA1 (0.41) | CHEK2HRH3KMT2A | |
| SCHEMBL11447883 | 0.81 | LTA4H (0.50) | CHEK2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713494-B1 | SUCH AS 6-HYDROXY-2-(4-HYDROXYPHENYL)-3-(4-(2-PIPERIDINYL-ETHOXY)BENZOYL)BENZOTHIOPHENE HYDROCHLORIDE SALT; OSTEO-POROSIS | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| EP-0826682-B1 | Amorphous Bentothiophene, method of preparation and method of use. | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-1998008513-A1 | AMORPHOUS BENZOTHIOPHENES, METHODS OF PREPARATION, AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0826682-A1 | Amorphous benzothiophenes, methods of preparation, and methods of use | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |