Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698 | 0.85 | MEN1 (0.38) | ALDH1A1SMN1; SMN2MAPTRAB9ATDP1 | |
| SCHEMBL2087 | 0.84 | EPHX1 (0.35) | LPAR1LPAR3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6943 | 0.84 | EPHX1 (0.35) | LPAR1LPAR3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11802 | 0.81 | CYP1A2 (0.33) | ALDH1A1SMN1; SMN2MAPTRAB9ATDP1 | |
| SCHEMBL6561 | 0.80 | LPAR1 (0.34) | NR1I2LPAR1LPAR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7386 | 0.79 | SMN1; SMN2 (0.38) | NR1I2LPAR1LPAR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL6814 | 0.78 | CYP1A2 (0.31) | TDP1CYP2C9CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1925 | 0.74 | LPAR1 (0.36) | LPAR1LPAR3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1909 | 0.74 | LPAR1 (0.36) | LPAR1LPAR3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6734 | 0.74 | ADRB2 (0.38) | LPAR1LPAR3ALDH1A1SMN1; SMN2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |