Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | KIF11 | P52732 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951936 | 0.83 | ESR2 (0.61) | PTPN5ESR2ARALDH1A1CCR6 | |
| SCHEMBL31410710 | 0.82 | ESR2 (0.76) | PTPN5ESR2ARALDH1A1KDM4E | |
| SCHEMBL19797926 | 0.81 | ESR2 (0.59) | PTPN5ESR2KIF11ARALDH1A1 | |
| SCHEMBL6561050 | 0.81 | ESR2 (0.59) | PTPN5ESR2ARALDH1A1KDM4E | |
| SCHEMBL4450175 | 0.81 | KIF11 (0.75) | PTPN5KIF11ARALDH1A1MAPT | |
| SCHEMBL4200280 | 0.81 | KIF11 (0.50) | PTPN5ESR2KIF11ALDH1A1MAPT | |
| SCHEMBL29876988 | 0.81 | KIF11 (0.53) | PTPN5KIF11ARALDH1A1MAPT | |
| SCHEMBL27848327 | 0.81 | CTSS (0.51) | PTPN5ESR2ARALDH1A1MAPT | |
| SCHEMBL7599697 | 0.80 | ESR2 (0.58) | PTPN5ESR2ARALDH1A1MAPT | |
| SCHEMBL17840160 | 0.80 | KIF11 (0.68) | KIF11ALDH1A1KDM4ECYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110494442-B | Peptide macrocycles and their use in the treatment of bacterial infections | 豪夫迈·罗氏有限公司 | 2023-07-25 | — | — | CN | disclosed |
| EP-1223158-B1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | BAYER CHEMICALS AG (DE) | 2004-08-11 | — | — | EP | disclosed |
| JP-2004067521-A | METHOD FOR PRODUCING 2-CARBOXY-4'-(TRIFLUOROMETHYL)BIPHENYL | ASAHI GLASS CO LTD | 2004-03-04 | — | — | JP | disclosed |
| US-6580002-B2 | Dihalo-, cyano- and methyl- substituted biphenyl chemical intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 2003-06-17 | — | — | US | disclosed |
| US-20030055285-A1 | Process for the preparation of trifiuoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles | LANXESS DEUTSCHLAND GMBH (DE) | 2003-03-20 | — | — | US | disclosed |
| US-6465688-B2 | CONVERTING METHYL-SUBSTITUTED BIPHENYLCARBONITRILES TO A TRICHLOROMETHYL- AND HYDROLYZING TO CORRESPONDING CARBOXY ACIDS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-15 | — | — | US | disclosed |
| US-20020095052-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS AND NOVEL TRICHLOROMETHYL - AND TRIFLUOROMETHYL - SUBSTITUTED BIPHENYLCARBONITRILES | LANXESS DEUTSCHLAND GMBH (DE) | 2002-07-18 | — | — | US | disclosed |
| EP-1223158-A1 | Process for preparing trifluoromethyl substituted biphenyl carboxylic acids and novel trichloromethyl and trifluoromethyl substituted biphenyl nitriles | Bayer Aktiengesellschaft (DE) | 2002-07-17 | — | — | EP | disclosed |
| EP-0106140-B1 | BENZOIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-08-17 | — | — | EP | disclosed |
| EP-0106140-A2 | Benzoic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-04-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055285-A1 | Process for the preparation of trifiuoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles | CPSF1, CYP2F1, CYP4F2 | PTPN5 2170/4885ESR2 3683/4885KIF11 1968/4885 |
| US-20020095052-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED BIPHENYLCARBOXYLIC ACIDS AND NOVEL TRICHLOROMETHYL - AND TRIFLUOROMETHYL - SUBSTITUTED BIPHENYLCARBONITRILES | MCCC2, CYP2F1, CYP4F2 | PTPN5 2557/4885ESR2 2903/4885KIF11 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.