Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6561289

C[SiH](C)[Ti+2](C1C=Cc2ccccc21)C1C=Cc2ccccc21.[Cl-].[Cl-]

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.31
CHRM1 known ✓ P11229 1/20 0.31
CHRM3 known ✓ P20309 1/20 0.31
SLC6A2 known ✓ P23975 1/20 0.31
SLC6A3 known ✓ Q01959 1/20 0.31
HTR2A P28223 2/20 0.33
HTR6 P50406 1/20 0.33
SIGMAR1 Q99720 4/20 0.31
KDM4E B2RXH2 2/20 0.31
BRD4 O60885 1/20 0.31
CCL2 P13500 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
DRD2 P14416 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
NFKB1 P19838 1/20 0.31
HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride Ion SCHEMBL1130520 0.96 HTR2A (0.33) HTR2AHTR6SIGMAR1KDM4EBRD4
SCHEMBL7630020 0.95 HTR6 (0.33) HTR2AHTR6SIGMAR1KDM4EBRD4
SCHEMBL7633756 0.82
Hydrochloric Acid SCHEMBL30630878 0.78 HTR2A (0.39) HTR2AHTR6SIGMAR1KDM4EBRD4
Hydrochloric Acid SCHEMBL7217280 0.76
Hydrochloric Acid SCHEMBL5853685 0.75 SIGMAR1 (0.32) SIGMAR1
Hydrochloric Acid SCHEMBL2538854 0.75 HTR2A (0.36) HTR2AHTR6SIGMAR1KDM4EBRD4
Hydrochloric Acid SCHEMBL7769222 0.75 HTR2A (0.36) HTR2AHTR6SIGMAR1KDM4EBRD4
Hydrochloric Acid SCHEMBL4460443 0.74 HTR2A (0.33) HTR2AHTR6SIGMAR1KDM4EBRD4
Hydrochloric Acid SCHEMBL714328 0.74 HTR2A (0.33) HTR2AHTR6SIGMAR1KDM4EBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6683016-B1 SLURRYING METALLOCENE AND ACTIVATOR, APPLYING SONIC WAVES OR VIBRATION WAVES, WASHING WITH HYDROCARBON SOLVENT, DRYING; EVEN PENETRATION INTO PORE SPACE OF SUPPORT DAELIM INDUSTRIAL CO., LTD. (KR) 2004-01-27 US disclosed
EP-1042375-B1 SUPPORTED METALLOCENE CATALYST, ITS PREPARATION METHOD AND OLEFIN POLYMERIZATION THEREWITH DAELIM IND CO LTD (KR) 2004-01-02 EP disclosed
EP-0795564-B1 Process for hydrogenation of conjugated diene polymers and catalyst compositions suitable for use therein SHELL INT RESEARCH (NL) 2001-01-10 EP disclosed
EP-1042375-A1 SUPPORTED METALLOCENE CATALYST, ITS PREPARATION METHOD AND OLEFIN POLYMERIZATION THEREWITH DAELIM INDUSTRIAL CO., LTD. (KR) 2000-10-11 EP disclosed
WO-2000023483-A1 SUPPORTED METALLOCENE CATALYST, ITS PREPARATION METHOD AND OLEFIN POLYMERIZATION THEREWITH DAELIM INDUSTRIAL CO., LTD. (KR) 2000-04-27 WO disclosed
US-5925717-A SELECTIVE HYDROGENATION OF POLYMERS WITH TITANIUM CATALYSTS WITH INDENE COMPOUND LIGANDS SHELL OIL COMPANY (US) 1999-07-20 US disclosed
US-5869417-A REACTING THE SURFACE OF A ZEOLITE CARRIER HAVING CRYSTALLINE PORES WITH AN ORGANIC ALUMINUM COMPOUND IN A SOLVENT AND IN THE PRESENCE OF AN INERT GAS; IMPREGNATING A METALLOCENE IN A SOLVENT; DRYING KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1999-02-09 US disclosed
US-5672669-A CONTACTING ETHYLENE WITH A SPRAY DRIED METALLOCENE CATALYST AND A COCATALYST CAPABLE OF ACTIVATING THE CATALYST, AND AN INERT FILLER PARTICLES, HOMO OR COPOLYMERIZATION UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-09-30 US disclosed
EP-0795564-A1 Process for hydrogenation of conjugated diene polymers and catalyst compositions suitable for use therein SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1997-09-17 EP disclosed
US-5648310-A Spray dried, filled metallocene catalyst composition for use in polyolefin manufacture UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-07-15 US disclosed