⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249207 | 0.72 | — | — | |
| SCHEMBL13225351 | 0.72 | — | — | |
| SCHEMBL1069856 | 0.72 | — | — | |
| SCHEMBL2856266 | 0.72 | — | — | |
| SCHEMBL8483278 | 0.69 | METAP2 (0.31) | — | |
| SCHEMBL11774495 | 0.69 | — | — | |
| SCHEMBL5401941 | 0.69 | METAP2 (0.31) | — | |
| SCHEMBL11504897 | 0.64 | LMNA (0.32) | — | |
| SCHEMBL7060097 | 0.63 | — | — | |
| SCHEMBL1128608 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892786-B1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | ABBOTT GMBH & CO KG (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6686369-B1 | α-hydrdroxylic acid derivatives, their production and use | ABBOTT GMBH & CO., KG (DE) | 2004-02-03 | — | — | US | disclosed |
| US-6610691-B1 | Inhibit binding of endothelin to receptor; treating hypertension | BASF AKTIENGESELLSCHAFT (DE) | 2003-08-26 | — | — | US | disclosed |
| EP-0892787-B1 | NOVEL ALPHA-HYDROXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | ABBOTT GMBH & CO KG (DE) | 2003-06-11 | — | — | EP | disclosed |
| US-6440975-B1 | Amino acid derivatives, the preparation and use thereof as endothelin antagonists | ABBOTT LABORATORIES | 2002-08-27 | — | — | US | disclosed |
| EP-0892786-A1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1999-01-27 | — | — | EP | disclosed |
| EP-0874829-A1 | AMINO ACID DERIVATIVES, THE PREPARATION AND USE THEREOF AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997038980-A1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-23 | — | — | WO | disclosed |
| WO-1997012878-A1 | AMINO ACID DERIVATIVES, THE PREPARATION AND USE THEREOF AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-10 | — | — | WO | disclosed |