SCHEMBL6561814

SCHEMBL6561814

CNC(=O)C#Cc1cccc2ccccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 1/20 0.49
ALDH1A1 P00352 4/20 0.45
GAA P10253 2/20 0.45
PGR P06401 1/20 0.45
PTGS1 P23219 1/20 0.45
MAPK1 P28482 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ACACB O00763 1/20 0.44
CHAT P28329 1/20 0.43
MTNR1A P48039 2/20 0.41
KDM4E B2RXH2 4/20 0.40
RAB9A P51151 3/20 0.40
NPC1 O15118 1/20 0.40
GRM5 P41594 1/20 0.40
KMT2A Q03164 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
MMP3 P08254 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6560705 0.81 ALDH1A1 (0.41) PLK1ALDH1A1GAAPGRPTGS1
SCHEMBL7833808 0.79 NR4A1 (0.47) ALDH1A1GAAACACBCHATKDM4E
SCHEMBL29749080 0.79 NR4A1 (0.47) ALDH1A1GAAACACBCHATKDM4E
SCHEMBL6563215 0.77 FFAR1 (0.42) ALDH1A1GAAKDM4ERAB9ANPC1
SCHEMBL5881377 0.76 CA1 (0.50) ALDH1A1HSD17B10ACACBCHATKDM4E
SCHEMBL28670332 0.74 ACACB (0.43) PLK1ALDH1A1GAAPGRPTGS1
SCHEMBL29661843 0.73 CHAT (0.60) ALDH1A1HSD17B10ACACBCHATKDM4E
SCHEMBL2776015 0.73 CHAT (0.60) ALDH1A1HSD17B10ACACBCHATKDM4E
SCHEMBL852937 0.73 ALDH1A1 (0.49) ALDH1A1GAAMAPK1ACACBCHAT
SCHEMBL6364668 0.71 CHAT (0.58) ALDH1A1HSD17B10ACACBCHATKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0944581-A4 PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES LILLY CO ELI (US) 2004-09-08 EP disclosed
US-6069247-A REACTING AN ACETYLENECARBOXY AMIDE AND AN ARYL OR HETEROCYCLYL HALIDE OR A GROUP ENHANCING THE ELECTROPHILICITY OF THE ATOM TO WHICH IT IS ATTACHED FOR DISPLACEMENT; USING A PALLADIUM COMPOUND CATALYST, A BASE AND AN ACID ELI LILLY AND COMPANY (US) 2000-05-30 US disclosed
EP-0944581-A1 PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES ELI LILLY AND COMPANY (US) 1999-09-29 EP disclosed
US-5917038-A REACTING PROPIOLAMIDE WITH ACTIVATED AROMATIC RING IN THE PRESENCE OF A PALLADIUM CATALYST ELI LILLY AND COMPANY (US) 1999-06-29 US disclosed
WO-1998022429-A1 PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES ELI LILLY AND COMPANY (US) 1998-05-28 WO disclosed