Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 12/20 | 0.34 |
| ▸ | F10 | P00742 | 10/20 | 0.34 |
| ▸ | PLAU | P00749 | 6/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.33 |
| ▸ | PLAT | P00750 | 4/20 | 0.33 |
| ▸ | F7 | P08709 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 3/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670894 | 0.90 | ITGB3 (0.39) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL6565998 | 0.89 | ITGB3 (0.37) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL6565368 | 0.89 | ITGB3 (0.37) | ITGB3ITGA2BF2F10F7 | |
| SCHEMBL6565399 | 0.88 | ITGB3 (0.37) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL7676164 | 0.86 | PTPN11 (0.30) | — | |
| SCHEMBL6563523 | 0.86 | ITGB3 (0.37) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL6563366 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL6563559 | 0.84 | ITGB3 (0.36) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL6565445 | 0.83 | ITGB3 (0.36) | ITGB3ITGA2BF2F10PLAU | |
| SCHEMBL6563089 | 0.83 | PLAU (0.33) | ITGB3ITGA2BF2F10PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |