Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BID | P55957 | 3/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.35 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198 | 0.70 | ALDH1A1 (1.00) | MCL1MEN1ALDH1A1KMT2ADNMT1 | |
| Acetic Acid SCHEMBL9119537 | 0.67 | KMT2A (0.76) | MCL1MEN1ALDH1A1KMT2ADNMT1 | |
| Tetrabuthylammonium SCHEMBL796640 | 0.67 | MEN1 (0.49) | MCL1MEN1ALDH1A1KMT2ADNMT1 | |
| SCHEMBL3320154 | 0.66 | ALDH1A1 (0.91) | MCL1MEN1ALDH1A1KMT2ADNMT1 | |
| SCHEMBL24079188 | 0.63 | PRKCI (0.46) | MCL1MEN1ALDH1A1KMT2ADNMT1 | |
| SCHEMBL20741249 | 0.63 | MAPT (0.63) | MCL1MEN1KMT2AMAPTHTT | |
| Nonane SCHEMBL29227378 | 0.63 | PTGS2 (0.46) | MEN1ALDH1A1KMT2AMAPTHTT | |
| SCHEMBL26059359 | 0.62 | HTR2A (0.58) | MCL1MEN1KMT2AMAPTHTT | |
| SCHEMBL29906204 | 0.62 | ALDH1A1 (0.70) | MCL1MEN1ALDH1A1KMT2ADNMT1 | |
| SCHEMBL5858623 | 0.62 | ALDH1A1 (0.70) | MCL1MEN1ALDH1A1KMT2ADNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154778-B1 | PHARMACEUTICAL PREPARATION CONTAINING DITHRANOL | ESPARMA GMBH (DE) | 2004-05-12 | — | — | EP | disclosed |
| US-6413950-B1 | TOPICAL APPLICATION; SKIN DISORDERS | ESPARMA GMBH (DE) | 2002-07-02 | — | — | US | disclosed |
| EP-1154778-A2 | PHARMACEUTICAL PREPARATION CONTAINING DITHRANOL | Esparma GmbH (DE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050018-A2 | PHARMACEUTICAL PREPARATION CONTAINING DITHRANOL | ESPARMA GMBH (DE) | 2000-08-31 | — | — | WO | disclosed |