Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.41 |
| ▸ | WNT3A | P56704 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.37 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5869606 | 0.81 | SLC6A4 (0.59) | RAB9AMEN1KMT2ASLC6A4 | |
| Oxalic Acid SCHEMBL5869405 | 0.81 | SLC6A4 (0.59) | RAB9AMEN1KMT2ASLC6A4 | |
| SCHEMBL5869414 | 0.80 | MRGPRX4 (0.41) | MRGPRX4CTNNB1WNT3ACA12CA2 | |
| SCHEMBL5869614 | 0.80 | MRGPRX4 (0.41) | MRGPRX4CTNNB1WNT3ACA12CA2 | |
| Oxalic Acid SCHEMBL7315983 | 0.80 | SLC6A4 (0.46) | MEN1KMT2ASLC6A4SLC6A9 | |
| SCHEMBL5394251 | 0.79 | HTR2A (0.45) | RAB9ASLC6A4 | |
| SCHEMBL5869711 | 0.76 | SLC6A4 (0.45) | MRGPRX4CTNNB1WNT3ACA12CA2 | |
| SCHEMBL5869336 | 0.76 | SLC6A4 (0.45) | MRGPRX4CTNNB1WNT3ACA12CA2 | |
| SCHEMBL7049659 | 0.72 | SLC6A4 (0.53) | SLC6A4 | |
| SCHEMBL8559444 | 0.71 | MRGPRX4 (0.45) | MRGPRX4CTNNB1WNT3ACA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397129-A1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094262-A1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |