Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869336 | 1.00 | SLC6A4 (0.45) | SLC6A4MRGPRX4CTNNB1WNT3ACA12 | |
| SCHEMBL5869289 | 0.90 | SLC6A4 (0.42) | SLC6A4MRGPRX4SLC6A9SLC7A5SLC6A2 | |
| SCHEMBL5869273 | 0.90 | SLC6A4 (0.42) | SLC6A4MRGPRX4SLC6A9SLC7A5SLC6A2 | |
| SCHEMBL6006366 | 0.82 | SLC6A4 (0.49) | SLC6A4SLC7A5SLC6A2SLC6A3KCNK2 | |
| Oxalic Acid SCHEMBL5869606 | 0.80 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| Oxalic Acid SCHEMBL5869405 | 0.80 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3KCNK2KCNH2 | |
| SCHEMBL5664924 | 0.77 | SLC6A4 (0.70) | SLC6A4SLC6A9SLC6A2SLC6A3 | |
| Oxalic Acid SCHEMBL6561979 | 0.76 | MRGPRX4 (0.42) | SLC6A4MRGPRX4CTNNB1WNT3ACA12 | |
| SCHEMBL6004073 | 0.75 | SLC6A4 (0.61) | SLC6A4SLC7A5SLC6A2SLC6A3KCNK2 | |
| SCHEMBL8202643 | 0.75 | SLC6A4 (0.61) | SLC6A4SLC7A5SLC6A2SLC6A3KCNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037932-B2 | Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1397129-B1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ADRA2C, ADRB1, TPH1 | SLC6A4 7/4885MRGPRX4 1237/4885CTNNB1 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.