Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049659 | 0.92 | SLC6A4 (0.53) | SLC6A4SLC7A5 | |
| SCHEMBL5533205 | 0.83 | SLC6A9 (0.46) | SLC6A4SLC7A5SLC6A9MEN1KMT2A | |
| Oxalic Acid SCHEMBL5288252 | 0.82 | CYP2D6 (0.51) | SLC6A4SLC6A9MEN1KMT2A | |
| SCHEMBL5530174 | 0.82 | SLC6A4 (0.43) | SLC6A4 | |
| Oxalic Acid SCHEMBL11688695 | 0.82 | SLC6A4 (0.51) | SLC6A4MTNR1AMTNR1BFFAR1MEN1 | |
| Maleic Acid SCHEMBL11238099 | 0.80 | LMNA (0.45) | MTNR1AMTNR1BFFAR1 | |
| SCHEMBL5394251 | 0.80 | HTR2A (0.45) | SLC6A4SLC7A5 | |
| Oxalic Acid SCHEMBL6561979 | 0.80 | MRGPRX4 (0.42) | SLC6A4SLC6A9MEN1KMT2A | |
| SCHEMBL4734874 | 0.78 | SLC6A4 (0.66) | SLC6A4SLC7A5SLC6A9MEN1KMT2A | |
| SCHEMBL13050366 | 0.78 | SLC6A4 (0.66) | SLC6A4SLC7A5SLC6A9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |