SCHEMBL656200

SCHEMBL656200

[C]1=COc2ccccc2-c2ccccc21

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MAPK1 P28482 1/20 0.32
ATM Q13315 1/20 0.32
HSP90AA1 P07900 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9369306 0.68 KDM4E (0.34) KDM4EMAPK1ATMHSP90AA1
SCHEMBL31023619 0.64 KDM4E (0.38) KDM4ELMNATDP1MAPK1ATM
SCHEMBL122449 0.64
SCHEMBL102781 0.61 MEN1 (0.37) KDM4ELMNATDP1MAPK1ATM
SCHEMBL30969099 0.61 KDM4E (0.44) KDM4ELMNATDP1MAPK1ATM
SCHEMBL20756367 0.61 KDM4E (0.44) KDM4ELMNATDP1MAPK1ATM
SCHEMBL3058111 0.61 KDM4E (0.44) KDM4ELMNATDP1MAPK1ATM
SCHEMBL5841466 0.61 DRD2 (0.37) KDM4ELMNATDP1MAPK1ATM
SCHEMBL6315604 0.60 PKM (0.41) KDM4ELMNATDP1MAPK1ATM
SCHEMBL6315597 0.60 PKM (0.41) KDM4ELMNATDP1MAPK1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 295 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113321658-B Dibenzooxepidine fluorescent functional molecule and preparation and application thereof 华南农业大学 2022-03-25 CN claimed
CN-113321658-A Dibenzooxepidine fluorescent functional molecule and preparation and application thereof 华南农业大学 2021-08-31 CN claimed
US-20210198235-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF AURANSA INC. 2021-07-01 US claimed
WO-2019103897-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF AURANSA INC. (US) 2019-05-31 WO claimed
US-6498190-B1 TREATMENT OF NASAL OCCLUSION AND MAST CELL DYSFUNCTION DISEASES; ANTIINFLAMMATORY AGENTS SHIONOGI & CO., LTD. (JP) 2002-12-24 US claimed
US-5872115-A COMPOUNDS FOR TREATMENT OF HYPERCHOLESTEROLEMIA, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISEASE OR ATHEROSCLEROSIS GRELAN PHARMACEUTICAL CO. LTD. (JP) 1999-02-16 US claimed
EP-0837052-A1 BICYCLIC AMINO DERIVATIVES AND PGD 2 ANTAGONIST CONTAINING THE SAME SHIONOGI & CO., LTD. (JP) 1998-04-22 EP claimed
EP-0742208-A1 2-Ureido-benzamide derivatives GRELAN PHARMACEUTICAL CO., LTD. (JP) 1996-11-13 EP claimed
US-4560447-A Electrolytic process for preparation of α-alkylated acetic acid derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1985-12-24 US claimed
US-20240231224-A9 HALOGEN-AND ALIPHATIC-CONTAINING ORGANOTIN PHOTORESISTS AND METHODS THEREOF LAM RESEARCH CORPORATION 2024-07-11 US disclosed
WO-2024137876-A2 SURFACE MODIFICATION OF METAL CATALYSTS WITH HYDROPHOBIC LIGANDS OR IONOMERS TWELVE BENEFIT CORPORATION (US) 2024-06-27 WO disclosed
US-20240200208-A1 CO2 PURIFICATION AND REDUCTION SYSTEMS SUMITOMO MITSUI BANKING CORPORATION 2024-06-20 US disclosed
US-20240192590-A1 APPARATUS AND PROCESS FOR EUV DRY RESIST SENSITIZATION BY GAS PHASE INFUSION OF A SENSITIZER LAM RESEARCH CORPORATION 2024-06-13 US disclosed
WO-2024123514-A1 CO2 PURIFICATION AND REDUCTION SYSTEMS TWELVE BENEFIT CORPORATION (US) 2024-06-13 WO disclosed
EP-0742208-A1 2-Ureido-benzamide derivatives GRELAN PHARMACEUTICAL CO., LTD. (JP) 1996-11-13 EP disclosed
EP-0742208-A1 2-Ureido-benzamide derivatives GRELAN PHARMACEUTICAL CO., LTD. (JP) 1996-11-13 EP disclosed
EP-0107134-B1 TRICYCLIC ANTIDEPRESSANT DRUG IMMUNOGENS, ANTIBODIES, LABELED CONJUGATES, AND RELATED DERIVATIVES MILES LABORATORIES, INC. (US) 1986-04-09 EP disclosed
US-4560447-A Electrolytic process for preparation of α-alkylated acetic acid derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1985-12-24 US disclosed
US-4495281-A CONTAINS DIBENZO(A,D)CYCLOHEPTENE; DIBENZ!B,F) AZEPINE AND DIBENZ(B,E)OXEPIN RINGS MILES LABORATORIES, INC. (US) 1985-01-22 US disclosed
EP-0107134-A1 Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives MILES LABORATORIES, INC. (US) 1984-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210198235-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF THPO, PIR, PAK6 KDM4E 636/4885LMNA 2273/4885TDP1 4438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.