Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5949446 | 0.99 | KMT2A (0.52) | KMT2ANPC1RAB9AGSK3BHDAC3 | |
| SCHEMBL6342190 | 0.91 | KMT2A (0.46) | KMT2ANPC1RAB9AGSK3BHDAC3 | |
| SCHEMBL11619439 | 0.84 | KMT2A (0.52) | KMT2ANPC1RAB9AGSK3BHDAC3 | |
| SCHEMBL6562435 | 0.83 | NPC1 (0.50) | KMT2ANPC1RAB9AGSK3BLMNA | |
| SCHEMBL6561313 | 0.82 | CES2 (0.54) | KMT2ANPC1RAB9AGSK3BHDAC3 | |
| SCHEMBL6561361 | 0.82 | L3MBTL1 (0.54) | KMT2ANPC1RAB9AGSK3BLMNA | |
| SCHEMBL2562144 | 0.82 | SMN1; SMN2 (0.47) | KMT2ANPC1RAB9AGSK3BHDAC3 | |
| Iodide SCHEMBL5949437 | 0.82 | NPC1 (0.49) | KMT2ANPC1RAB9AGSK3BLMNA | |
| Iodide SCHEMBL5949248 | 0.81 | CES2 (0.53) | KMT2ANPC1RAB9AGSK3BHDAC3 | |
| Iodide SCHEMBL5949473 | 0.81 | L3MBTL1 (0.53) | KMT2ANPC1RAB9AGSK3BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1050531-B1 | Pyridine and piperidine derivatives for treating neurodegenerative diseases | SERVIER LAB (FR) | 2004-11-17 | — | — | EP | disclosed |
| EP-1050531-A1 | Pyridine and piperidine derivatives for treating neurodegenerative diseases | ADIR ET COMPAGNIE (FR) | 2000-11-08 | — | — | EP | disclosed |