Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.54 |
| ▸ | METAP1 | P53582 | 7/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | LAP3 | P28838 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939440 | 0.82 | METAP2 (0.56) | METAP2METAP1 | |
| SCHEMBL7308710 | 0.81 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL6488439 | 0.81 | METAP2 (0.70) | METAP2METAP1LTA4HALDH1A1MAPT | |
| SCHEMBL6937335 | 0.80 | METAP2 (0.46) | METAP2METAP1 | |
| SCHEMBL6937626 | 0.79 | METAP2 (0.47) | METAP2METAP1KMT2ALMNA | |
| SCHEMBL7075750 | 0.77 | METAP2 (0.49) | METAP2METAP1MEN1KMT2A | |
| SCHEMBL6564913 | 0.76 | METAP2 (0.53) | METAP2METAP1ALDH1A1 | |
| SCHEMBL6565042 | 0.76 | METAP2 (0.51) | METAP2METAP1 | |
| SCHEMBL6940131 | 0.75 | METAP2 (0.50) | METAP2METAP1MEN1KMT2A | |
| SCHEMBL6942554 | 0.75 | METAP2 (0.45) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |