Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 17/20 | 0.47 |
| ▸ | METAP1 | P53582 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939440 | 0.87 | METAP2 (0.56) | METAP2METAP1 | |
| SCHEMBL6937335 | 0.85 | METAP2 (0.46) | METAP2METAP1 | |
| SCHEMBL6932840 | 0.84 | METAP2 (0.44) | METAP2METAP1 | |
| SCHEMBL6942554 | 0.81 | METAP2 (0.45) | METAP2METAP1 | |
| SCHEMBL6564913 | 0.81 | METAP2 (0.53) | METAP2METAP1KDM4E | |
| SCHEMBL7308710 | 0.80 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL7075750 | 0.79 | METAP2 (0.49) | METAP2METAP1KMT2A | |
| SCHEMBL6563019 | 0.79 | METAP2 (0.54) | METAP2METAP1KMT2ALMNA | |
| SCHEMBL6565042 | 0.78 | METAP2 (0.51) | METAP2METAP1 | |
| SCHEMBL6940131 | 0.77 | METAP2 (0.50) | METAP2METAP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |