Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 0.62 |
| ▸ | METAP1 | P53582 | 12/20 | 0.62 |
| ▸ | LAP3 | P28838 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477521 | 0.77 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL6476261 | 0.76 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL6563175 | 0.72 | METAP2 (0.62) | METAP2METAP1 | |
| SCHEMBL16836977 | 0.70 | ALPI (0.54) | ANPEPRNPEPDNPEP | |
| SCHEMBL6561815 | 0.70 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL11651848 | 0.69 | NPC1 (0.50) | — | |
| SCHEMBL6477700 | 0.68 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL6476862 | 0.68 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL6478044 | 0.66 | METAP2 (0.81) | METAP2METAP1 | |
| SCHEMBL6486535 | 0.66 | METAP2 (0.69) | METAP2METAP1LAP3ANPEPRNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |