Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.42 |
| ▸ | METAP1 | P53582 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074814 | 0.87 | METAP2 (0.42) | METAP2METAP1KDM4E | |
| SCHEMBL6477922 | 0.78 | METAP2 (0.54) | METAP2METAP1KDM4E | |
| SCHEMBL6941281 | 0.70 | METAP2 (0.48) | METAP2METAP1 | |
| SCHEMBL6562847 | 0.70 | METAP2 (0.48) | METAP2METAP1 | |
| SCHEMBL6940254 | 0.69 | METAP2 (0.52) | METAP2METAP1 | |
| SCHEMBL6938806 | 0.68 | GAA (0.38) | METAP2METAP1KDM4E | |
| SCHEMBL6563040 | 0.68 | METAP2 (0.47) | METAP2METAP1 | |
| SCHEMBL6563437 | 0.66 | METAP2 (0.44) | METAP2METAP1 | |
| SCHEMBL6932840 | 0.66 | METAP2 (0.44) | METAP2METAP1 | |
| SCHEMBL6935924 | 0.66 | METAP2 (0.40) | METAP2METAP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |