Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 12/20 | 0.48 |
| ▸ | METAP1 | P53582 | 10/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563437 | 0.82 | METAP2 (0.44) | METAP2METAP1 | |
| SCHEMBL6489121 | 0.78 | METAP2 (0.77) | METAP2METAP1SMN1; SMN2 | |
| SCHEMBL6564913 | 0.77 | METAP2 (0.53) | METAP2METAP1ALDH1A1 | |
| SCHEMBL6562847 | 0.75 | METAP2 (0.48) | METAP2METAP1 | |
| SCHEMBL6563040 | 0.75 | METAP2 (0.47) | METAP2METAP1RAB9A | |
| SCHEMBL6940254 | 0.72 | METAP2 (0.52) | METAP2METAP1L3MBTL1 | |
| SCHEMBL6937951 | 0.72 | METAP2 (0.46) | METAP2METAP1TSHR | |
| SCHEMBL7308710 | 0.72 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL6563403 | 0.70 | METAP2 (0.42) | METAP2METAP1 | |
| SCHEMBL6937335 | 0.70 | METAP2 (0.46) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |