Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 6/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.48 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12768028 | 0.73 | KEAP1 (0.81) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL6563603 | 0.72 | KEAP1 (0.45) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL3257185 | 0.70 | KEAP1 (0.70) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL4954209 | 0.70 | KEAP1 (0.70) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL5158052 | 0.69 | LMNA (0.79) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL2477690 | 0.69 | LMNA (0.70) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL8626209 | 0.69 | LMNA (0.72) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL30486834 | 0.69 | LMNA (0.70) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL23555177 | 0.68 | KEAP1 (1.00) | KEAP1NFE2L2SQSTM1LMNAHPGD | |
| SCHEMBL10143424 | 0.68 | KEAP1 (0.72) | KEAP1NFE2L2SQSTM1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |