Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.46 |
| ▸ | F2 | P00734 | 5/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668378 | 0.90 | PLAU (0.49) | PLAUPRSS1F2PRSS2PRSS3 | |
| SCHEMBL6561828 | 0.86 | MLYCD (0.44) | PLAUPRSS1F2PRSS2PRSS3 | |
| SCHEMBL6565051 | 0.81 | F10 (0.50) | PRSS1F2F10 | |
| SCHEMBL6563250 | 0.78 | PLAU (0.54) | PLAUPRSS1F2PRSS2PRSS3 | |
| SCHEMBL6563422 | 0.76 | PRSS1 (0.42) | PLAUPRSS1F2PRSS2PRSS3 | |
| SCHEMBL6565690 | 0.76 | PLAU (0.54) | PLAUPRSS1F2PRSS2PRSS3 | |
| SCHEMBL7672235 | 0.74 | PLAU (0.49) | PLAUF2F10ITGB3ITGA2B | |
| SCHEMBL6563528 | 0.73 | PRSS1 (0.51) | PLAUPRSS1F2PRSS2PRSS3 | |
| SCHEMBL6771396 | 0.72 | PLAU (0.49) | PLAUF2F10HTTITGB3 | |
| SCHEMBL6565956 | 0.72 | PLAU (0.49) | PLAUF2F10HTTITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |