Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | PLAT | P00750 | 2/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | PROC | P04070 | 1/20 | 0.37 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563250 | 0.92 | PLAU (0.54) | PLAUITGB3ITGA2BF2HTT | |
| SCHEMBL6565956 | 0.90 | PLAU (0.49) | PLAUITGB3ITGA2BF2HTT | |
| SCHEMBL7678092 | 0.85 | F2 (0.40) | PLAUF2RAB9AF10PLG | |
| SCHEMBL6565392 | 0.85 | PLAU (0.44) | PLAUITGB3ITGA2BF2HTT | |
| SCHEMBL6561886 | 0.84 | PLAU (0.53) | PLAUITGB3ITGA2BF2HTT | |
| SCHEMBL6563229 | 0.82 | PLAU (0.37) | PLAUHTTSIRT2NPC1PKM | |
| SCHEMBL6565486 | 0.82 | PLAU (0.41) | PLAUITGB3ITGA2BF2HTT | |
| SCHEMBL7809949 | 0.80 | SLC6A3 (0.42) | PLAUF2HTTSIRT2NPC1 | |
| SCHEMBL6561871 | 0.79 | KMT2A (0.46) | HTTSIRT2KMT2AF10 | |
| SCHEMBL7672248 | 0.79 | F2 (0.40) | PLAUF2F10PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |