Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626909 | 0.92 | TSHR (0.70) | TSHRPOLBCA2CA12CA1 | |
| SCHEMBL4901678 | 0.84 | TSHR (0.81) | TSHRPOLBKLK7MEN1KMT2A | |
| SCHEMBL317876 | 0.81 | TSHR (0.66) | TSHRKLK7KMT2ATDP1SMN1; SMN2 | |
| SCHEMBL10309729 | 0.78 | TSHR (0.70) | TSHRPOLBKLK7MEN1KMT2A | |
| SCHEMBL5175026 | 0.78 | TSHR (0.76) | TSHRPOLBCA2KLK7MEN1 | |
| SCHEMBL14010060 | 0.78 | TSHR (0.70) | TSHRPOLBKLK7MEN1KMT2A | |
| SCHEMBL10369206 | 0.76 | TSHR (0.68) | TSHRPOLBKLK7MEN1KMT2A | |
| SCHEMBL27255868 | 0.76 | TSHR (0.68) | TSHRPOLBKLK7MEN1KMT2A | |
| SCHEMBL29197989 | 0.76 | TSHR (0.68) | TSHRPOLBKLK7MEN1KMT2A | |
| SCHEMBL27455918 | 0.76 | TSHR (0.68) | TSHRPOLBKLK7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040234592-A1 | Mixture containing thyroid hormone , ethanolamine and emulsifier | KARO BIO AB (SE) | 2004-11-25 | — | — | US | claimed |
| EP-1404413-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2004-04-07 | — | — | EP | claimed |
| EP-1398024-A2 | Uses for thyroid hormone compounds | KARO BIO AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-0831769-B1 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KAROBIO AB (SE) | 2003-10-15 | — | — | EP | claimed |
| WO-2002089917-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2002-11-14 | — | — | WO | claimed |
| CN-101291640-A | Thyroxine compounds for the treatment of burns and fat deposits in humans | THOMAS LAVIN (US) | 2008-10-22 | — | — | CN | disclosed |
| US-20040234592-A1 | Mixture containing thyroid hormone , ethanolamine and emulsifier | KARO BIO AB (SE) | 2004-11-25 | — | — | US | disclosed |
| EP-1404413-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002089917-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2002-11-14 | — | — | WO | disclosed |