Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | FGB | P02675 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335770 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL6564086 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL8630313 | 0.77 | KDM4E (0.51) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL30288437 | 0.77 | KDM4E (0.51) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL8556578 | 0.75 | KMT2A (0.52) | ALDH1A1KDM4EGAAHPGDKMT2A | |
| SCHEMBL10970985 | 0.74 | ALOX5 (0.53) | ALDH1A1KDM4EGAAHPGDKMT2A | |
| SCHEMBL16654428 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL6563671 | 0.72 | KDM4C (0.48) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL12315105 | 0.72 | TNF (0.47) | ALDH1A1KDM4EGAAHPGDKMT2A | |
| SCHEMBL6601700 | 0.71 | ALDH1A1 (0.54) | ALDH1A1KDM4EGAAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |