Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 7/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549260 | 0.83 | EGLN1 (0.39) | EGLN1EGLN3HIF1ANRXFP1BBOX1 | |
| SCHEMBL8785457 | 0.83 | KDM4C (0.45) | KDM4CKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6564086 | 0.79 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6567209 | 0.76 | KDM4C (0.58) | KDM4CEGLN1KDM4EALDH1A1MEN1 | |
| SCHEMBL821712 | 0.76 | KDM4C (0.58) | KDM4CEGLN1KDM4EALDH1A1MEN1 | |
| SCHEMBL8784892 | 0.73 | TLR8 (0.43) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6567506 | 0.72 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4070937 | 0.71 | FTO (0.57) | EGLN1ALDH1A1GAAFTOEGLN3 | |
| SCHEMBL4076740 | 0.69 | EGLN1 (0.44) | KDM4CEGLN1KDM4EALDH1A1MEN1 | |
| SCHEMBL8779261 | 0.69 | EGLN1 (0.38) | EGLN1FTOEGLN3EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |