SCHEMBL6564638

SCHEMBL6564638

Clc1ccc(-c2ccc(Cl)cc2-c2ccccc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.61
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
POLB P06746 1/20 0.49
HTT P42858 1/20 0.49
MAP4K4 O95819 1/20 0.49
S100A4 P26447 1/20 0.47
PTGDR2 Q9Y5Y4 1/20 0.46
PTGS2 P35354 2/20 0.46
PTGS1 P23219 1/20 0.46
LMNA P02545 2/20 0.45
GAA P10253 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
HPGD P15428 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
TSHR P16473 2/20 0.44
CYP2A6 P11509 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9509941 1.00 CYP1A2 (0.61) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL20023630 0.95 CYP1A2 (0.61) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL5050876 0.95 CYP1A2 (0.52) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL31677416 0.91 S100A4 (0.57) CYP1A2KDM4EALDH1A1SMN1; SMN2S100A4
SCHEMBL25246242 0.89 CYP1A2 (0.65) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL30202105 0.89 CYP1A2 (0.65) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL24999271 0.89 CYP1A2 (0.65) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL21944074 0.88 CYP1A2 (0.70) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL24972708 0.88 MAPT (0.49) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL26805880 0.88 ALDH1A1 (0.52) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1122746-B1 Composition for film formation and insulating film JSR CORP (JP) 2004-09-22 EP disclosed
US-6468589-B2 A HEAT-CURED POLYETHER BASED ON A 9,9-BIS(P-HYDROXYPHENYL)-FLUORENE HAVING AT LEAST ONE ALKYL SUBSTITUENT AND A DIHYDROXY AROMATIC COMONOMER; LOW DIELECTRIC PROTECTIVE COATINGS; HEAT RESISTANCE; NONCRACKING JSR CORPORATION (JP) 2002-10-22 US disclosed
US-20010012870-A1 Composition for film formation and insulating film JSR CORPORATION (JP) 2001-08-09 US disclosed
EP-1122746-A1 Composition for film formation and insulating film JSR Corporation (JP) 2001-08-08 EP disclosed
EP-0330345-B1 Process for producing aromatic polymer compounds MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) 1995-05-03 EP disclosed
US-5109109-A Process for producing aromatic or heterocyclic polymer with metal halides MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1992-04-28 US disclosed
US-5066776-A From dihaloaromatic compound, in situ generation of alkali sulfides BAYER AKTIENGESELLSCHAFT (DE) 1991-11-19 US disclosed
US-5053566-A Catalysis reaction with bromine or chlorine halogenating agent, in the presence of methylene chloride and metal cation containing Type-L zeolite BAYER AKTIENGESELLSCHAFT (DE) 1991-10-01 US disclosed
EP-0414079-A2 Process of preparation of polyarylene sulfides BAYER AG (DE) 1991-02-27 EP disclosed
EP-0330345-A2 Process for producing aromatic polymer compounds MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1989-08-30 EP disclosed
US-3957666-A HYDRAULIC FLUIDS, HEAT TRANSFER FLUIDS MONSANTO COMPANY (US) 1976-05-18 US disclosed