SCHEMBL9509941

SCHEMBL9509941

Clc1ccc(-c2cc(Cl)ccc2-c2ccccc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.61
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
POLB P06746 1/20 0.49
HTT P42858 1/20 0.49
MAP4K4 O95819 1/20 0.49
S100A4 P26447 1/20 0.47
PTGDR2 Q9Y5Y4 1/20 0.46
PTGS2 P35354 2/20 0.46
PTGS1 P23219 1/20 0.46
LMNA P02545 2/20 0.45
GAA P10253 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
HPGD P15428 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
TSHR P16473 2/20 0.44
CYP2A6 P11509 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6564638 1.00 CYP1A2 (0.61) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL20023630 0.95 CYP1A2 (0.61) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL5050876 0.95 CYP1A2 (0.52) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL31677416 0.91 S100A4 (0.57) CYP1A2KDM4EALDH1A1SMN1; SMN2S100A4
SCHEMBL25246242 0.89 CYP1A2 (0.65) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL30202105 0.89 CYP1A2 (0.65) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL24999271 0.89 CYP1A2 (0.65) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL21944074 0.88 CYP1A2 (0.70) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL24972708 0.88 MAPT (0.49) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL26805880 0.88 ALDH1A1 (0.52) CYP1A2KDM4EALDH1A1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0423479-B1 METHOD FOR THE PRODUCTION OF 4,4'-DIHALOGENATED OLIGOPHENYLS BAYER AG (DE) 1993-08-11 EP disclosed
US-5053566-A Catalysis reaction with bromine or chlorine halogenating agent, in the presence of methylene chloride and metal cation containing Type-L zeolite BAYER AKTIENGESELLSCHAFT (DE) 1991-10-01 US disclosed