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SCHEMBL6564722

SCHEMBL6564722

N[C@H](CC1CCCCC1)C(O)C(=O)NOC(Cc1ccccc1)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ METAP2 P50579 12/20 0.64
▸ METAP1 P53582 7/20 0.64
▸ LTA4H P09960 1/20 0.46
▸ MME P08473 1/20 0.45
▸ ACE P12821 1/20 0.45
▸ CPA1 P15085 1/20 0.45
▸ ACE2 Q9BYF1 1/20 0.45
▸ SRR Q9GZT4 2/20 0.44
▸ REN P00797 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6477146 0.83 METAP2 (0.70) METAP2METAP1LTA4H
SCHEMBL7351459 0.83 MME (0.62) METAP2METAP1LTA4HMMEACE
SCHEMBL7351453 0.83 MME (0.62) METAP2METAP1LTA4HMMEACE
Hydrochloric Acid SCHEMBL7354336 0.82 MME (0.61) METAP2METAP1LTA4HMMEACE
Hydrochloric Acid SCHEMBL7354328 0.82 MME (0.61) METAP2METAP1LTA4HMMEACE
SCHEMBL6561718 0.81 METAP2 (0.55) METAP2METAP1REN
SCHEMBL6485564 0.78 METAP2 (1.00) METAP2METAP1
SCHEMBL24307966 0.78 SRR (0.47) LTA4HMMEACECPA1ACE2
SCHEMBL7353859 0.78 METAP2 (0.65) METAP2METAP1
SCHEMBL6488309 0.78 METAP2 (0.65) METAP2METAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1272456-B1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2004-10-27 — — EP claimed