Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | FABP1 | P07148 | 1/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6302647 | 0.98 | KDM4E (0.67) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL6754929 | 0.83 | KDM4E (0.69) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL6420641 | 0.83 | KDM4E (0.69) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL7093029 | 0.77 | TAAR1 (0.50) | KDM4ENPSR1CYP2D6RPS6KB1GAA | |
| SCHEMBL1831586 | 0.75 | KDM4E (0.46) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL14993886 | 0.73 | KDM4E (0.56) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL5981398 | 0.73 | KDM4E (0.56) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL10594962 | 0.73 | KDM4E (0.56) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| SCHEMBL21652270 | 0.72 | KDM4E (0.55) | KDM4EHTTNPSR1L3MBTL1CYP2D6 | |
| Alcohol SCHEMBL14813490 | 0.71 | KDM4E (0.54) | KDM4EHTTNPSR1L3MBTL1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268429-B1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2004-08-18 | — | — | EP | disclosed |
| EP-1268429-A1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001079172-A1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER Departament Brevets/Fontanes (FR) | 2001-10-25 | — | — | WO | disclosed |
| EP-0432442-A1 | ACAT inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-06-19 | — | — | EP | disclosed |