Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519456 | 0.91 | NR1H3 (0.43) | NR1H3KDM4ESLC6A4HRH3 | |
| SCHEMBL6512055 | 0.90 | NR1H3 (0.45) | NR1H3MEN1KMT2AKDM4EPARP14 | |
| SCHEMBL6515545 | 0.90 | NR1H3 (0.44) | NR1H3MEN1KMT2APARP14SLC6A4 | |
| SCHEMBL6515170 | 0.89 | NR1H3 (0.44) | NR1H3MEN1KMT2ACHEK2PARP14 | |
| SCHEMBL6519566 | 0.88 | NR1H3 (0.42) | NR1H3GPR119 | |
| SCHEMBL6515253 | 0.85 | OPRK1 (0.51) | NR1H3KMT2ACHEK2 | |
| SCHEMBL6567185 | 0.84 | NR1H3 (0.43) | NR1H3MEN1KMT2ASLC6A4HRH3 | |
| SCHEMBL6515535 | 0.81 | NR1H3 (0.46) | NR1H3MEN1KMT2AKDM4E | |
| SCHEMBL6515000 | 0.81 | NR1H3 (0.51) | NR1H3KDM4E | |
| SCHEMBL6566798 | 0.80 | NR1H3 (0.45) | NR1H3PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |