Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566798 | 0.88 | NR1H3 (0.45) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6515545 | 0.87 | NR1H3 (0.44) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6512055 | 0.84 | NR1H3 (0.45) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6564859 | 0.84 | NR1H3 (0.42) | NR1H3MEN1KMT2AHRH3SLC6A4 | |
| SCHEMBL6515170 | 0.83 | NR1H3 (0.44) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6519456 | 0.82 | NR1H3 (0.43) | NR1H3KCNH2OPRM1ALDH1A1HRH3 | |
| SCHEMBL6515253 | 0.82 | OPRK1 (0.51) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6566799 | 0.80 | NR1H3 (0.54) | NR1H3MEN1KMT2AALDH1A1RXRA | |
| SCHEMBL6519566 | 0.80 | NR1H3 (0.42) | NR1H3OPRK1OPRM1OPRD1ALDH1A1 | |
| SCHEMBL6567271 | 0.80 | NR1H3 (0.52) | NR1H3OPRK1KCNH2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |