Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513607 | 0.91 | NR1H3 (0.46) | NR1H3TACR1AGTR2FKBP1ACCR5 | |
| SCHEMBL6564837 | 0.90 | NR1H3 (0.53) | NR1H3OPRK1OPRM1OPRD1TACR1 | |
| SCHEMBL6567185 | 0.88 | NR1H3 (0.43) | NR1H3OPRK1OPRM1OPRD1KCNH2 | |
| SCHEMBL6515545 | 0.86 | NR1H3 (0.44) | NR1H3PARP14OPRK1OPRM1OPRD1 | |
| SCHEMBL6515253 | 0.86 | OPRK1 (0.51) | NR1H3OPRK1OPRM1OPRD1KCNH2 | |
| SCHEMBL6515170 | 0.84 | NR1H3 (0.44) | NR1H3PARP14OPRK1OPRM1OPRD1 | |
| SCHEMBL6512055 | 0.83 | NR1H3 (0.45) | NR1H3PARP14OPRK1OPRM1OPRD1 | |
| SCHEMBL6519566 | 0.83 | NR1H3 (0.42) | NR1H3OPRK1OPRM1OPRD1MET | |
| SCHEMBL6567271 | 0.82 | NR1H3 (0.52) | NR1H3OPRK1OPRM1OPRD1KCNH2 | |
| SCHEMBL6519456 | 0.81 | NR1H3 (0.43) | NR1H3OPRM1KCNH2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |