Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 4/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563072 | 0.89 | VDR (0.53) | VDRCD274PDCD1MAPTMAPK1 | |
| SCHEMBL6563045 | 0.88 | VDR (0.47) | VDRCD274PDCD1MAPTMAPK1 | |
| SCHEMBL27587237 | 0.82 | VDR (0.34) | VDRCD274PDCD1MAPTMAPK1 | |
| SCHEMBL6563022 | 0.81 | VDR (0.47) | VDRCD274PDCD1MAPTMAPK1 | |
| SCHEMBL6564607 | 0.80 | VDR (0.57) | VDRMRGPRX4 | |
| SCHEMBL6564928 | 0.79 | VDR (0.64) | VDR | |
| SCHEMBL7612427 | 0.79 | CD274 (0.40) | CD274PDCD1 | |
| SCHEMBL7604546 | 0.78 | CD274 (0.40) | VDRCD274PDCD1 | |
| SCHEMBL7612422 | 0.78 | CD274 (0.40) | VDRCD274PDCD1MAPTMAPK1 | |
| SCHEMBL6562993 | 0.78 | VDR (0.65) | VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831106-B1 | Selective activity on cell proliferation and differentiation without displaying any hypercalcaemiant nature | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-12-14 | — | — | US | claimed |
| EP-1235777-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2004-06-16 | — | — | EP | claimed |
| US-6831106-B1 | Selective activity on cell proliferation and differentiation without displaying any hypercalcaemiant nature | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-12-14 | — | — | US | disclosed |
| EP-1235777-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2004-06-16 | — | — | EP | disclosed |
| EP-1235777-A2 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038303-A2 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2001-05-31 | — | — | WO | disclosed |