Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567448 | 0.86 | TLR8 (0.53) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL8968152 | 0.81 | TLR8 (0.48) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL180365 | 0.80 | TLR8 (0.65) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL8785457 | 0.80 | KDM4C (0.45) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL8784892 | 0.80 | TLR8 (0.43) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL27511729 | 0.79 | TLR8 (0.62) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL11167917 | 0.77 | TLR8 (0.49) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL9335770 | 0.77 | ALDH1A1 (0.46) | TLR8SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL8627406 | 0.75 | TLR8 (0.54) | TLR8RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL8127607 | 0.74 | ALDH1A1 (0.43) | TLR8RAB9ASMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |