Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.51 |
| ▸ | RXRB | P28702 | 10/20 | 0.51 |
| ▸ | RXRG | P48443 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565507 | 0.88 | ALOX5 (0.46) | RXRARXRBRXRGALDH1A1ALOX5 | |
| SCHEMBL14445463 | 0.78 | RXRA (0.78) | RXRARXRBRXRGNR1H4ALOX5 | |
| SCHEMBL6563544 | 0.72 | RXRA (0.38) | RXRARXRBRXRGALDH1A1FABP3 | |
| SCHEMBL14728118 | 0.72 | RXRA (0.80) | RXRARXRBRXRGNR1H4ALOX5 | |
| SCHEMBL14445464 | 0.70 | RXRA (0.63) | RXRARXRBRXRGALOX5CNR1 | |
| SCHEMBL9522392 | 0.70 | RXRA (0.81) | RXRARXRBRXRGALOX5FABP3 | |
| SCHEMBL8689127 | 0.69 | CA9 (0.79) | RXRARXRBRXRGPTGS1CA1 | |
| SCHEMBL4009771 | 0.68 | RXRA (0.57) | RXRARXRBRXRGCNR2SLC16A3 | |
| SCHEMBL9353438 | 0.68 | RXRA (0.55) | RXRARXRBRXRGALOX5PTGS1 | |
| SCHEMBL878054 | 0.68 | RXRA (0.71) | RXRARXRBRXRGALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |