Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.42 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565332 | 0.88 | RXRA (0.51) | ALOX5PTGS1ALDH1A1SLC16A3SLC16A1 | |
| SCHEMBL24408917 | 0.78 | NR1H4 (0.54) | ALOX5PTGS1ALDH1A1PTPN1TSHR | |
| SCHEMBL9941646 | 0.76 | ALOX5 (0.69) | ALOX5PTGS1CA9 | |
| SCHEMBL6563546 | 0.74 | F10 (0.38) | ALOX5PTGS1ALDH1A1SLC16A3SLC16A1 | |
| SCHEMBL24409337 | 0.69 | LMNA (0.49) | ALOX5ALDH1A1PTPN1MEN1KMT2A | |
| SCHEMBL24419766 | 0.68 | NR1H4 (0.50) | ALOX5PTGS1ALDH1A1TSHRLMNA | |
| SCHEMBL5382607 | 0.67 | PTGS2 (0.76) | ALOX5PTGS1RXRARXRBRXRG | |
| Succinic Acid Diethyl Ester SCHEMBL27940678 | 0.67 | SMN1; SMN2 (0.62) | ALDH1A1PTPN1TSHRMEN1KMT2A | |
| SCHEMBL24425215 | 0.67 | LMNA (0.44) | PTGS1ALDH1A1SLC16A3SLC16A1TSHR | |
| SCHEMBL9941629 | 0.67 | CA9 (0.69) | ALOX5PTGS1TSHRLMNACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |