Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 6/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565392 | 0.91 | PLAU (0.44) | PLAUNQO2SIRT2F2ITGB3 | |
| SCHEMBL6565956 | 0.87 | PLAU (0.49) | PLAUSIRT2F2ITGB3ITGA2B | |
| SCHEMBL6565367 | 0.86 | TSHR (0.31) | PLAUTSHRSENP1MEN1KMT2A | |
| SCHEMBL7806866 | 0.85 | NR1I2 (0.40) | SIRT2F2TSHRSENP1 | |
| SCHEMBL6563250 | 0.82 | PLAU (0.54) | PLAUNQO2SIRT2F2ITGB3 | |
| SCHEMBL6565690 | 0.82 | PLAU (0.54) | PLAUNQO2SIRT2F2ITGB3 | |
| SCHEMBL6561673 | 0.77 | PRSS1 (0.35) | F2ITGB3ITGA2BF10TSHR | |
| SCHEMBL6563144 | 0.76 | ITGB3 (0.38) | PLAUNQO2F2ITGB3ITGA2B | |
| SCHEMBL7672248 | 0.76 | F2 (0.40) | PLAUF2F10 | |
| SCHEMBL6561967 | 0.75 | F2 (0.42) | PLAUNQO2F2F10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |