SCHEMBL6565732

SCHEMBL6565732

O=C(Cl)Oc1ccc(-c2ccc(OC(=O)Cl)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.47
KIF11 P52732 1/20 0.44
KMT2A Q03164 6/20 0.42
MEN1 O00255 3/20 0.42
RAB9A P51151 2/20 0.41
LMNA P02545 4/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GAA P10253 2/20 0.39
FABP7 O15540 1/20 0.38
FABP3 P05413 1/20 0.38
FABP5 Q01469 1/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
HTT P42858 2/20 0.37
ELANE P08246 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6924446 0.92 RAB9A (0.46) HSD17B10KMT2AMEN1RAB9ALMNA
SCHEMBL5665614 0.91 ELANE (0.44) HSD17B10KMT2AMEN1SMN1; SMN2HTT
SCHEMBL1347723 0.91 KMT2A (0.53) HSD17B10KMT2AMEN1RAB9ALMNA
SCHEMBL6223085 0.89 ESR2 (0.54) RAB9ALMNASMN1; SMN2GAANPC1
SCHEMBL14684639 0.85 PARP10 (0.55) HSD17B10KMT2AALDH1A1
SCHEMBL6564201 0.84 ELANE (0.52) KMT2AMEN1RAB9ALMNASMN1; SMN2
SCHEMBL25236596 0.82 GAA (0.56) KMT2AMEN1RAB9ASMN1; SMN2NPSR1
SCHEMBL59462 0.82 ELANE (0.48) KMT2AMEN1SMN1; SMN2HTTELANE
SCHEMBL9578961 0.82 MAPT (0.50) HSD17B10KMT2AMEN1RAB9ALMNA
SCHEMBL3292329 0.80 ALDH1A1 (0.43) HSD17B10KMT2ARAB9ASMN1; SMN2ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0119271-B1 LIQUID CRYSTALLINE POLYMER COMPOSITIONS, PROCESS, AND PRODUCTS SRI INTERNATIONAL (US) 1990-07-11 EP claimed
EP-1375563-A1 Insulation material for aluminum and copper metallizations Infineon Technologies AG (DE) 2004-01-02 EP disclosed
EP-0457334-B1 Carbonates of acetylenic alcohols NIPPON PAINT CO LTD (JP) 1994-08-10 EP disclosed
US-5258542-A Carbonates of acetylenic alcohols NIPPON PAINT CO., LTD. (JP) 1993-11-02 US disclosed
US-5194653-A Useful in making heat resistant liquid crystalline polymers NIPPON PAINT COMPANY, LIMITED (JP) 1993-03-16 US disclosed
EP-0457334-A1 Carbonates of acetylenic alcohols NIPPON PAINT CO., LTD. (JP) 1991-11-21 EP disclosed