Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30463822 | 0.83 | NPC1 (0.78) | POLBNPC1RAB9AL3MBTL1MAPK1 | |
| SCHEMBL11313646 | 0.82 | POLB (0.72) | POLBNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL31503975 | 0.81 | LMNA (0.78) | POLBNPC1RAB9ALMNAMAPK1 | |
| SCHEMBL3498895 | 0.81 | LMNA (0.78) | NPC1RAB9ALMNAMAPK1MEN1 | |
| SCHEMBL11309805 | 0.79 | NPC1 (0.72) | POLBNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL5645175 | 0.78 | LMNA (0.69) | POLBNPC1RAB9ALMNAMAPK1 | |
| SCHEMBL27541541 | 0.77 | ALOX15 (0.65) | NPC1RAB9AL3MBTL1LMNAMEN1 | |
| SCHEMBL4345396 | 0.77 | POLB (0.63) | POLBNPC1LMNAMEN1KMT2A | |
| SCHEMBL4347822 | 0.77 | KMT2A (0.68) | POLBRAB9AL3MBTL1LMNAMEN1 | |
| SCHEMBL9400403 | 0.76 | NPC1 (0.61) | POLBNPC1RAB9AL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |