Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568583 | 0.87 | ALOX5 (0.58) | MAPTRXFP1MGLLSMN1; SMN2TP53 | |
| SCHEMBL4505884 | 0.86 | TP53 (0.52) | MAPTNPC1RAB9AGAANFKB1 | |
| SCHEMBL6524162 | 0.85 | NAMPT (0.57) | MAPTNPC1RAB9AGAAMEN1 | |
| SCHEMBL6526530 | 0.85 | MAPT (0.51) | MAPTNPC1RAB9AGAAMEN1 | |
| SCHEMBL6568636 | 0.85 | KDM4E (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6519124 | 0.84 | MAPT (0.47) | MAPTNPC1RAB9AKDM4EMMP2 | |
| SCHEMBL4347962 | 0.83 | MAPT (0.48) | MAPTNPC1RAB9AGAAMEN1 | |
| SCHEMBL4348870 | 0.83 | MAPT (0.47) | MAPTNPC1RAB9AGAAMEN1 | |
| SCHEMBL6565522 | 0.83 | RAB9A (0.56) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL4350091 | 0.81 | MAPT (0.53) | MAPTNPC1RAB9AGAANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |