Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566878 | 0.87 | MAPT (0.53) | ALOX5EPHX2MAPTTP53SMN1; SMN2 | |
| SCHEMBL6524162 | 0.82 | NAMPT (0.57) | MAPTTP53SMN1; SMN2LMNAMGLL | |
| SCHEMBL6519124 | 0.80 | MAPT (0.47) | MAPTTP53SMN1; SMN2LMNATHRB | |
| SCHEMBL4350091 | 0.78 | MAPT (0.53) | MAPTTP53SMN1; SMN2LMNARXFP1 | |
| SCHEMBL13239642 | 0.77 | ALOX5 (0.70) | ALOX5EPHX2MAPTSMN1; SMN2LMNA | |
| SCHEMBL4505884 | 0.77 | TP53 (0.52) | MAPTTP53SMN1; SMN2LMNATHRB | |
| SCHEMBL6526530 | 0.76 | MAPT (0.51) | MAPTTP53SMN1; SMN2LMNATHRB | |
| SCHEMBL6568636 | 0.75 | KDM4E (0.49) | MAPTTP53SMN1; SMN2LMNATHRB | |
| SCHEMBL12470970 | 0.74 | RAB9A (0.64) | MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL12846731 | 0.74 | MAPT (0.50) | MAPTTP53SMN1; SMN2LMNAMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |